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Almost one-third of new drugs approved by U.S. regulators over a decade ended up years later with warnings about unexpected, sometimes life-threatening side effects or complications, a new analysis found. The results covered all 222 prescription drugs approved by the U.S. Food and Drug Administration from 2001 through 2010 . The withdrawn drugs and the reason: Bextra, an anti-inflammatory medicine, heart problems; Raptiva, a psoriasis drug, rare nervous system illness; and Zelnorm, a bowel illness drug, heart problems.Safety issues were most common for psychiatric drugs and biologic drugs – made from living cells rather than chemicals – than for older drug types. Moore, a senior scientist for drug safety and policy at the Institute for Safe Medication Practices, said the new results raise concerns about whether new drugs are being extensively tested before approval.
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