In this Oct. 9, 2018 file photo, an embryo receives a small dose of Cas9 protein and PCSK9 sgRNA in a microscope in a laboratory in Shenzhen in southern China's Guangdong province, during work by scientist He Jiankui's team. (AP/Mark Schiefelbein)
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People with a DNA mutation that reduces their chance of HIV infection may die sooner, according to a study that suggests tinkering with a gene to try to fix one problem may cause others.The study authors cited the case of the Chinese researcher who tried to produce this mutation in twin girls before their birth, to reduce their risk for HIV. The Chinese scientist tried to create the same mutation, but failed. The girls now carry different alterations in the same gene.Past studies have suggested that carrying the mutation has some drawbacks, including a heightened risk of death from flu.Nielsen said the study does not apply to a form of gene therapy that differs from what the Chinese researcher did.In contrast, the people in Nielsen's study were living without a normal, working version of a gene, a condition the Chinese researcher sought to produce.
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