Summary
All have home advantage with Algeria facing Malawi in Blida, Cameroon playing Sierra Leone in Yaounde and South Africa meeting Congo Brazzaville in Polokwane.
Defending champions Nigeria, record seven-time title-holders Egypt and shock 2012 winners Zambia need home victories to keep alive hopes of qualifying.
Germany-born Cameroon coach Volker Finke wants a return to the form that delivered impressive victories over DR Congo and Ivory Coast when they play Sierra Leone.
He will look particularly to France-based strikers Vincent Aboubakar and Clinton N'Jie, scorers of three goals each in the qualifiers.
Strikers Bongani Ndulula and Tokelo Rantie struck the goals that conquered Congo in Pointe-Noire and are likely to start in a side that has not conceded a goal in three qualifiers.
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